2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0652
    Etonogestrel
    		99.91%
    Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).
    Etonogestrel
  • HY-103005S
    Ramelteon metabolite M-II-d3
    		99.78%
    Ramelteon metabolite M-II-d3 is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist.
    Ramelteon metabolite M-II-d<sub>3</sub>
  • HY-33914
    4-Hydroxymethylpyrazole
    		99.74%
    4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase.
    4-Hydroxymethylpyrazole
  • HY-15876
    Clopidogrel thiolactone
    		98.0%
    Clopidogrel thiolactone is an important intermediate in the metabolism of Clopidogrel (HY-15283). Clopidogrel thiolactone has antiplatelet aggregatione effects. Clopidogrel is a P2Y12 receptor inhibitor that exerts antiplatelet effects.
    Clopidogrel thiolactone
  • HY-142122
    Imipramine N-oxide
    		99.90%
    Imipramine N-oxide is the metabolite of Imipramine. Imipramine is a tertiary amine tricyclic antidepressant.
    Imipramine N-oxide
  • HY-101416
    Vanilpyruvic acid
    		98.28%
    Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.
    Vanilpyruvic acid
  • HY-W012187
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde
    		99.95%
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO) is a metabolite of Butylated hydroxytoluene (HY-Y0172) .
    3,5-Di-tert-butyl-4-hydroxybenzaldehyde
  • HY-W001080R
    3,4-Dihydroxybenzeneacetic acid (Standard)
    3,4-Dihydroxybenzeneacetic acid (Standard) is the analytical standard of 3,4-Dihydroxybenzeneacetic acid. This product is intended for research and analytical applications. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
    3,4-Dihydroxybenzeneacetic acid (Standard)
  • HY-124087
    (±)-2-Propyl-4-pentenoic acid
    		≥98.0%
    (±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity.
    (±)-2-Propyl-4-pentenoic acid
  • HY-B1109
    N-Acetylprocainamide
    		99.89%
    N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.
    N-Acetylprocainamide
  • HY-G0017S
    N-Desmethyl imatinib-d8
    		99.95%
    N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
    N-Desmethyl imatinib-d<sub>8</sub>
  • HY-I0177
    Vilazodone carboxylic acid
    		98.20%
    Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor).
    Vilazodone carboxylic acid
  • HY-100656
    Desmethyl cariprazine
    		98.08%
    Desmethyl cariprazine is an active metabolite of Cariprazine. Cariprazine, an antipsychotic agent candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).
    Desmethyl cariprazine
  • HY-W012982
    3-Amino-2-oxazolidinone
    		≥98.0%
    3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo. 3-Amino-2-oxazolidinone is orally active.
    3-Amino-2-oxazolidinone
  • HY-101108
    Tazarotenic acid
    		98.67%
    Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
    Tazarotenic acid
  • HY-135356
    m-Nifedipine
    		99.76%
    m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.
    m-Nifedipine
  • HY-145991
    Ribavirin carboxylic acid
    		99.42%
    Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity.
    Ribavirin carboxylic acid
  • HY-W087195
    Biprofen
    		99.87%
    Biprofen is a nonsteroidal anti-inflammatory agent.
    Biprofen
  • HY-N0917
    6''-O-Malonylgenistin
    		99.0%
    6''-O-Malonylgenistin (Malonylgenistin) is a glycosylated isoflavone and metabolite of Genistin (HY-N0595). 6''-O-Malonylgenistin activates hTAS2R39. 6''-O-Malonylgenistin can be used in the research of bitter taste.
    6''-O-Malonylgenistin
  • HY-Y1771
    2-Carboxybenzaldehyde
    		99.95%
    2-Carboxybenzaldehyde is a key intermediate metabolite in the biodegradation of polycyclic aromatic hydrocarbons (PAHs) such as fluoranthene and phenanthrene. 2-Carboxybenzaldehyde can be produced by the degradation of fluoranthene by Pasteurella sp. IFA and Mycobacterium sp. PYR-1. 2-Carboxybenzaldehyde can also be produced by the degradation of phenanthrene by Pseudomonas sp. PPD.
    2-Carboxybenzaldehyde
Cat. No. Product Name / Synonyms Application Reactivity